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Product Info Summary
| SKU: | A01208 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-P2X purinoceptor 7 P2RX7 Antibody
View all P2X7/P2RX7 Antibodies
SKU/Catalog Number
A01208
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-P2X purinoceptor 7 P2RX7 Antibody (Catalog # A01208). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
P2RX7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-P2X purinoceptor 7 P2RX7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01208)
Host
Rabbit
Contents
P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
P2RX7 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human P2RX7. The immunogen is located within the last 50 amino acids of P2RX7.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.
Reactive Species
A01208 is reactive to P2RX7 in Human, Mouse
Applications
A01208 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
68.585kDa
Background of P2X7/P2RX7
The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1). This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2). Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2). Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
P2RX7 antibody can be used for detection of P2RX7 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of P2RX7 in 3T3 cell lysate with P2RX7 antibody at (A) 1 and (B) 2 μg/ml.
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Immunocytochemistry of P2RX7 in 3T3 cells with P2RX7 antibody at 5 μg/mL.
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Immunofluorescence of P2RX7 in 3T3 cells with P2RX7 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For P2RX7 (Source: Uniprot.org, NCBI)
Gene Name
P2RX7
Full Name
P2X purinoceptor 7
Weight
68.585kDa
Superfamily
P2X receptor family
Alternative Names
ATP receptor; MGC20089; P2RX7; P2X purinoceptor 7; P2X7; P2X7P2X7 receptor; P2X7R; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A; Purinergic receptor P2RX7 P2X7 purinergic receptor P2X 7 P2X purinoceptor 7|ATP receptor|P2X7 receptor|P2Z receptor|purinergic receptor P2X, ligand gated ion channel, 7|purinergic receptor P2X7 variant A|purnergic receptor P2X 7
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on P2RX7, check out the P2RX7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for P2RX7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-P2X purinoceptor 7 P2RX7 Antibody (A01208)
Hello CJ!
A01208 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Zou Z,Wang Q,Zhou M,Li W,Zheng Y,Li F,Zheng S,He Z.Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression.J Gene Med.2020 Dec;22(12)
Species: Mouse
A01208 usage in article: APP:IHC, SAMPLE:LUNG TISSUE, DILUTION:1:1000
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